What doctors don’t know about the drugs they prescribe

TED Talk (13 minute video) …

The video’s producers say:

“When a new drug gets tested, the results of the trials should be published for the rest of the medical world — except much of the time, negative or inconclusive findings go unreported, leaving doctors and researchers in the dark. In this impassioned talk, Ben Goldacre [psychiatrist] explains why these unreported instances of negative data are especially misleading and dangerous.”

He cites, for example, all the trials over a 15-year period of 12 different antidepressants that were submitted to (and later approved by) the American Food & Drug Administration (FDA) as part of the authorisation package. There were 36 positive trial results and 38 negative. But in the peer-reviewed academic literature, only three of the negative trials were published, whilst in contrast all but one of the positive trials were published …


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