Results of World’s Largest Antidepressant Study Look Dismal

Dr. Joan Moncrieff, psychiatrist, writing for the Mad in America website, says:

“A few months ago I was surprised to receive a request from an obscure journal of consciousness studies to review a paper. I was surprised because, although it was not immediately obvious from the title, the paper contained the first reports of the primary outcome measure of the massive and notorious STAR-D study [Sequenced Treatment Alternatives to Relieve Depression – All Medication Levels], 14 years after the study was finished.

What in the world were the main findings of the world’s largest ever antidepressant trial doing being presented now in a little known journal? The answer may lie in the fact that they show how miserably poor the results of standard medical treatment for depression really are!

With 4,041 participants, the STAR-D study is by far the largest and most expensive study of antidepressants ever conducted. The intention of the study was to see how antidepressant treatment combined with high quality care performed in usual clinical conditions. It did not involve a placebo or any sort of control. All treatment was provided free for the duration of the study to maximise engagement …”

Read more here.

Results of World’s Largest Antidepressant Study Look Dismal
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