antidepressants

Placebo Effect – not antidepressants – responsible for depression improvement

This report by Peter Simons has been published by Mad in the UK. It begins: “In a study of fluoxetine (Prozac) for adolescents, researchers found that the placebo effect predicted good outcomes, but the actual drug treatment did not. After accounting…
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Suicide Rates and Prescription of Antidepressants

This study by Simone Amendola, Martin Plöderl, and Michael P. Hengartner has been published by Crisis (The Journal of Crisis Intervention and Suicide Prevention). The abstract says: “Background: Previous ecological studies reported that increasing antidepressant prescriptions were associated with decreasing suicide rates. …
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Watchful waiting for depression using depathologization, advice and shared decision making

Highlights: Watchful waiting was shown to be an effective first line of treatment for non-suicidal patients with depressive symptoms Patients already arrive with expectations so depathologization should be addressed Expectation of pharmacotherapy before the arrival was the main driver of…
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The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs

Authored by Mark Horowitz, and David M. Taylor, the world’s first antidepressants deprescribing guidelines for psychiatry are now available. The publishers say: “Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance…
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Probiotics for adults with major depressive disorder compared with antidepressants: a systematic review and network meta-analysis

This review has been published in the journal Oxford Academic. The abstract says: “Context: Despite recent advances in antidepressants in treating major depression (MDD), their usage is marred by adverse effects and social stigmas. Probiotics may be an efficacious adjunct or…
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Antidepressant withdrawal should be taken seriously – we’re investigating ways to help people come off the pills

This article from Mark Horowitz, Joanna Moncrieff and Katharine Wallis has been published by The Conversation. It begins: “Misinformation about antidepressants  is rife  and is probably fuelling their rise in use. Chief among these false ideas are: Antidepressant withdrawal effects are mild and…
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The influence of paid opinion leaders on the prescribing of antidepressants in the UK

A former NHS psychiatrist has submitted two rapid responses to the BMJ (British Medical Journal) in relation to  this published letter : Reversing the rate of antidepressant prescribing. The first response begins: “I see that there have been a number of responses to this letter: Reversing the rate…
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Rapid Response: No good argument for treating mild depression with antidepressants

A response – published in the British Medical Journal – to the argument put forward by Jauhar et al who support the current scale of antidepressant prescribing, including for mild conditions, and for those provoked by social and economic conditions:…
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