Early Intervention in Ultrahigh Risk for Psychosis Ineffective

Few transition to psychosis anyway, relapse rates were high after treatment, maintenance therapy was ineffective, and no treatment was more effective than any other.

This report from Peter Simons has has been published by Mad in America. It begins:

“In a new study in JAMA Psychiatry, researchers tested an increasingly intensive, multi-stage approach to early intervention for people at ‘ultrahigh risk’ of psychosis. Their findings? The intervention failed in every way.

‘In this sequential multiple assignment randomized trial including 342 individuals, a specialized psychological intervention (cognitive-behavioral case management [CBCM]) and a psychopharmacological intervention (CBCM and antidepressant medication) were not more efficacious than control conditions in improving remission and functional recovery. Relapse rates among individuals who remitted were high.

Despite being classed as ‘ultrahigh risk,’ few people transition to psychosis anyway. Moreover, the intervention didn’t lead to more remission, relapse rates were high for those who did remit after treatment, maintenance therapy after remission was no more effective than simple monitoring (watchful waiting), and no treatment (for instance, CBCM or drugs) was more effective than any other …”

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