Randomised Control Trials (RCTs)
RELEASE (REdressing Long-tErm Antidepressant uSE): protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 in general practice

The abstract for this research protocol (published by BMC) says: “Background Many people experience withdrawal symptoms when they attempt to stop antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing need for medication, contributing to long-term use (> 12 months). Long-term antidepressant use…
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Changing the topic does not change the facts

This letter to The Lancet Psychiatry (journal) comes from Dr. Jonanathan Shedler. It begins: “In a Comment published in The Lancet Psychiatry, Scott Lilienfeld and colleagues 1 wrote that I encouraged psychotherapists to ignore new practice guidelines for post-traumatic stress disorder (PTSD) because…
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Misreporting Results and Publication Bias Common in Psychiatry Research
My Mind Medicine Australia Psychedelic Lecture Tour

This article by Prof. David Nutt has been published by Drug Science. It begins: “I have just come back from a 3-week lecture tour of South-Eastern Australia supporting the cause of the charity Mind Medicine Australia (MMA) They have been raising money for psychedelic…
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Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial

This research paper has been published in eClinicalMedicine. The summary says: “Background Psilocybin has been suggested as a novel, rapid-acting treatment for depression. Two consecutive doses have been shown to markedly decrease symptom severity in an open-label setting or when compared to…
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ECT is a classic failure of evidence-based medicine

This Council for Evidence-Based Psychiatry has hosted a guest-blog by Prof. Richard Bentall, who writes: “In a discipline to which controversy is no stranger, there are few controversies guaranteed to generate as much heat as that surrounding the benefits and costs…
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‘Full Measure’: Fake science

“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgement of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly…
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Is medical research now beyond redemption?

“… without so called ‘evidence’ there is no seat at the guideline table. This is the fundamental ‘commissioning bias,’ the elephant in the room, because the drug industry controls and funds most research. So the drug industry and EBM [evidence…
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