depression

The helpful delusion: Evidence is growing that mental illness is more than dysfunction, with enormous implications for treatment

This article by Prof. Justin Garson has been published in Aeon magazine. It begins: “Most people thought my dad lived alone. He didn’t. He lived with God and the French actress Catherine Deneuve. They were outside of him but somehow projected…
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Withdrawal Syndrome Following Discontinuation of 28 Antidepressants: Pharmacovigilance Analysis of 31,688 Reports from the WHO Spontaneous Reporting Database

“Antidepressants are associated with an increased reporting of withdrawal syndrome compared with other drug classes.” This open-access research article by multiple co-authors has been provided by Springer Link. The abstract says: “Introduction Evidence is lacking on withdrawal syndrome related to individual antidepressants…
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Book Review: ‘Evidence-biased Antidepressant Prescription’ by Michael P. Hengartner

This book review by Marion Brown has been published by BJGP Life (which publishes comment and opinion on research and clinical care for the primary care community): “Hengartner begins ‘Over my academic career, I went into different stages of belief and disbelief.’…
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“Clear evidence” for serotonin hypothesis of depression?

This post by Dr. Eiko Fried has been published on his blog site Measurement, modeling & complexity of mental health. It begins: “There has been a 60 year long discussion on the role of the neurotransmitter serotonin in the pathophysiology of…
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Despite More Treatments for Depression, Prevalence Doesn’t Decrease—Why?

This article by Peter Simons has been published on the Mad in the UK website. It begins: “Between 1987 and 2007, the number of people receiving treatment for depression in the United States increased fourfold (and has continued to rise more…
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Magic-mushroom drug can treat severe depression, trial suggests

This report by Philippa Roxby comes from the BBC. It begins: “A drug based on a compound in hallucinogenic mushrooms can improve the symptoms of severe depression for up to 12 weeks, a trial shows. A 25mg tablet of psilocybin puts…
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Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants’ Efficacy and Harm

This paper by Michael Hengartner has been published in the journal Frontiers in Psychiatry. The abstract says: “Background In current psychiatric practice, antidepressants are widely and with ever-increasing frequency prescribed to patients. However, several scientific biases obfuscate estimates of antidepressants’ efficacy…
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More treatment but no less depression: The treatment-prevalence paradox

This article – by Johan Orme, Steven D. Hollon, Ronald C. Kessler, Pim Cuijpers, and Scott M. Monroe – has been published in the Clinical Psychology Review. The abstract says: “Treatments for depression have improved, and their availability has markedly increased…
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Personal Perspective on the Systematic Review of Serotonin Imbalance Hypothesis for depression and Mechanism of Action for Antidepressants

This interview with Dr. Mark Horowitz is conducted by Fauzia Khan and has been published in The Physician. The abstract says: “Fauzia Khan meets Dr Mark Horowitz, Trainee Psychiatrist and Clinical Research Fellow in the NHS. Mark talks about his journey…
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