“Clear evidence” for serotonin hypothesis of depression?

This post by Dr. Eiko Fried has been published on his blog site Measurement, modeling & complexity of mental health. It begins:

“There has been a 60 year long discussion on the role of the neurotransmitter serotonin in the pathophysiology of depression. A recent systematic investigation by Joanna Moncrief and colleagues concluded that ‘main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations’.

Yesterday, a new paper came out in which the authors made the strong claim that they found ‘clear evidence’ for the serotonin theory of depression, that is, that the neurotransmitter serotonin is involved in the pathophysiology of depression.

Less than 24 hours after the paper appeared online, there has already been substantial media coverage, such as a piece in the Guardian. Given the relevance of the study, I’ll explain in this blog post why the paper’s findings do not support the conclusion the authors draw …”

You can read more from here.

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