Joanna Moncrieff

The Serotonin Zombie: Authors of New Study Try to Breathe New Life into the Dead

Peter Simons reports for Mad in the UK: “In June, Joanna Moncrieff and others had appeared to put the final dagger into the low serotonin theory of depression (the so-called ;chemical imbalance’ theory). They reviewed fifty years of research into the…
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Beyond the Chemical Imbalance Theory of Depression: An Interview with Prof. Joanna Moncrieff

This interview , conducted by Justin Garson, has been published in Psychology Today. It begins: “KEY POINTS In 2022, a large review led by Joanna Moncrieff showed the ‘serotonin theory of depression’ to be groundless. Her review puts into question our…
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Response to Criticism of Our Serotonin Paper

This article by Joanna Moncrieff and Mark Horowitz has been published by Mad in America. It begins: “We recently published a  paper  finding that the serotonin hypothesis of depression (the idea that depression is caused by low serotonin or reduced serotonin activity)…
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Services for People Withdrawing From Antidepressants

“New study documents what antidepressant users need to help them come off safely.” Key Points: One in four people will experience severe withdrawal symptoms when trying to reduce or come off antidepressants. There are no specialized services to support people…
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“Clear evidence” for serotonin hypothesis of depression?

This post by Dr. Eiko Fried has been published on his blog site Measurement, modeling & complexity of mental health. It begins: “There has been a 60 year long discussion on the role of the neurotransmitter serotonin in the pathophysiology of…
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Personal Perspective on the Systematic Review of Serotonin Imbalance Hypothesis for depression and Mechanism of Action for Antidepressants

This interview with Dr. Mark Horowitz is conducted by Fauzia Khan and has been published in The Physician. The abstract says: “Fauzia Khan meets Dr Mark Horowitz, Trainee Psychiatrist and Clinical Research Fellow in the NHS. Mark talks about his journey…
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My adult ADHD drugs felt like a lifeline. Then came the scary side-effects …

“After a year on prescription stimulants, I started to unravel. Would a desperate experiment with street narcotics make me see things differently?” This article by Sophie Knight has been published in The Guardian. It begins: “At first being diagnosed with ADHD…
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How to take the news that depression has not been shown to be caused by a chemical imbalance

This article is from psychiatrist Dr. Joanna Moncrieff. It begins: “For decades people have been told that depression is caused by a serotonin deficiency. This was the rationale behind the introduction of the SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants in the…
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A Decisive Blow to the Serotonin Hypothesis of Depression

This article by Christopher Lane has been published in Psychology Today. It begins: “Almost as soon as it was floated in 1965 by Harvard psychiatrist Joseph Schildkraut, the serotonin hypothesis of  depression —reduced and simplified by pharma marketing to the ‘chemical imbalance’…
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Is the chemical imbalance an ‘urban legend’? An exploration of the status of the serotonin theory of depression in the scientific literature

This study/article by Benjamin Anga, MarkHorowitz and Joanna Moncrieff has been published in ScienceDirect. The abstract says: “The theory that depression is caused by a serotonin abnormality or other chemical imbalance has become widely accepted by the public and is one…
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