Research

Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial

This research paper has been published in eClinicalMedicine. The summary says: “Background Psilocybin has been suggested as a novel, rapid-acting treatment for depression. Two consecutive doses have been shown to markedly decrease symptom severity in an open-label setting or when compared to…
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Rethinking healthy eating in light of the gut microbiome

The importance of a good diet to mental health and wellbeing is well-established. This paper – published in Cell Host & Microbiome – looks at role played by the gut microbiome and reviews the evidence as to what makes for a…
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Estimating Risk of Antidepressant Withdrawal from a Review of Published Data

This article – from Mark Abie Horowitz, Adele Framer, Michael P. Hengartner, Anders Sørensen & David Taylor – has been published in the journal CNS Drugs. The abstract says: “Adaptation of the brain to the presence of a drug predicts withdrawal…
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The Effectiveness of an Intensive Inpatient Psychotherapy Program for Chronic Depression: A naturalistic comparison with wait list

This paper has been published by BMC Psychiatry. The abstract says: “Background Patients with chronic depression (CD) typically have an early symptom onset, more psychiatric comorbidities, more treatment attempts, and more frequent and longer inpatient hospitalizations than patients with major depressive…
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Withdrawal Syndrome Following Discontinuation of 28 Antidepressants: Pharmacovigilance Analysis of 31,688 Reports from the WHO Spontaneous Reporting Database

“Antidepressants are associated with an increased reporting of withdrawal syndrome compared with other drug classes.” This open-access research article by multiple co-authors has been provided by Springer Link. The abstract says: “Introduction Evidence is lacking on withdrawal syndrome related to individual antidepressants…
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“Clear evidence” for serotonin hypothesis of depression?

This post by Dr. Eiko Fried has been published on his blog site Measurement, modeling & complexity of mental health. It begins: “There has been a 60 year long discussion on the role of the neurotransmitter serotonin in the pathophysiology of…
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Despite More Treatments for Depression, Prevalence Doesn’t Decrease—Why?

This article by Peter Simons has been published on the Mad in the UK website. It begins: “Between 1987 and 2007, the number of people receiving treatment for depression in the United States increased fourfold (and has continued to rise more…
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Magic-mushroom drug can treat severe depression, trial suggests

This report by Philippa Roxby comes from the BBC. It begins: “A drug based on a compound in hallucinogenic mushrooms can improve the symptoms of severe depression for up to 12 weeks, a trial shows. A 25mg tablet of psilocybin puts…
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Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants’ Efficacy and Harm

This paper by Michael Hengartner has been published in the journal Frontiers in Psychiatry. The abstract says: “Background In current psychiatric practice, antidepressants are widely and with ever-increasing frequency prescribed to patients. However, several scientific biases obfuscate estimates of antidepressants’ efficacy…
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