antidepressants

Withdrawal Syndrome Following Discontinuation of 28 Antidepressants: Pharmacovigilance Analysis of 31,688 Reports from the WHO Spontaneous Reporting Database

“Antidepressants are associated with an increased reporting of withdrawal syndrome compared with other drug classes.” This open-access research article by multiple co-authors has been provided by Springer Link. The abstract says: “Introduction Evidence is lacking on withdrawal syndrome related to individual antidepressants…
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Doctor knows best, poisoned chalices, and beings on drugs: Young people’s accounts of getting the diagnosis of bipolar disorder

This account by JP Marshall of part of a research study has been published by Mad in the UK. It begins: “Not long ago, as part of a research study, I asked six young people how it was for them to…
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Book Review: ‘Evidence-biased Antidepressant Prescription’ by Michael P. Hengartner

This book review by Marion Brown has been published by BJGP Life (which publishes comment and opinion on research and clinical care for the primary care community): “Hengartner begins ‘Over my academic career, I went into different stages of belief and disbelief.’…
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“Clear evidence” for serotonin hypothesis of depression?

This post by Dr. Eiko Fried has been published on his blog site Measurement, modeling & complexity of mental health. It begins: “There has been a 60 year long discussion on the role of the neurotransmitter serotonin in the pathophysiology of…
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Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants’ Efficacy and Harm

This paper by Michael Hengartner has been published in the journal Frontiers in Psychiatry. The abstract says: “Background In current psychiatric practice, antidepressants are widely and with ever-increasing frequency prescribed to patients. However, several scientific biases obfuscate estimates of antidepressants’ efficacy…
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Celexa, Lexapro & the Death of Evidence-Based Medicine

This article has been published on the website of American legal firm Baum Hedlund Aristei & Goldman. It begins: “‘Oh, what a tangled web we weave. When first we practise to deceive!” From Walter Scott’s epic poem, Marmion. This is the story of…
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More treatment but no less depression: The treatment-prevalence paradox

This article – by Johan Orme, Steven D. Hollon, Ronald C. Kessler, Pim Cuijpers, and Scott M. Monroe – has been published in the Clinical Psychology Review. The abstract says: “Treatments for depression have improved, and their availability has markedly increased…
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Most people on antidepressants don’t need them: time to wean them off

This leader-article comes from The Economist. It begins: “Almost 35 years ago American drug regulators approved Prozac, the first in a series of blockbuster antidepressants known as selective serotonin re-uptake inhibitors (SSRIs). Prozac and its cousins were lauded by patients and…
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The hidden epidemic of sexual dysfunction which experts blame on SSRI antidepressants

Jo Macfarlane reports for the Mail on Sunday: SSRI antidepressants could cause ‘life-changing’ sexual problems experts say1 in 8 people were prescribed antidepressants in the past year according to statsBut they can cause serious side effects like libido drop and numb groin…
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Antidepressants Work Better Than Sugar Pills Only 15 Percent of the Time

This article by Adam Piore has been published in Newsweek magazine. It begins: “Five years ago Mark Horowitz seemed an unlikely skeptic of psycho-pharmaceuticals. He had been taking the popular antidepressant Lexapro virtually every day for 15 years. He was so…
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